What exactly do you feel on your bike, what's the problem(s)?
The weight on my hands and arms is never a problem. No hurting in my arms, no numbness in my hands, etc.

I feel neck and shoulder tiredness or discomfort, which could very well be just from changing from a hybrid to a road bike.

It seemed like my saddle was too low. My leg had a little more bend in it that I thought it should, so I raised it just a hair. Then I noticed discomfort in my shoulders, so I put it back down.

How much bend do you have in your arms when you ride? I did ask the bike shop guy about that and he said a little bit, but not much. His suggestion was to ride it a month and see how I adjusted.