I've now been off of depo for two months. I remember losing weight so rapidly a few years ago that co-workers worried that I might be anorexic, and I remember that I got off of depo for six months, but I don't recall if the time periods overlapped. I was also clinically depressed at the time, which ruins my appetite. I saw my doctor today about my cold, and she said she's happy to have me off the depo. (Turns out I have a viral bronchitis that's been making the rounds; joy! I should feel better by Sunday, she said.)