I too just recently bought a roadbike after yrs (45) of upright bikes - I love the lightness and the speed = I am still getting used to fit with regards to shoulders and neck. On one hand I can ride much easier (legs, seat, sheer endurance - I can go 30-50 miles without thinking about it) on road bike - but hybrid and folder are easier on my upper body. I am riding a Scott Contessa Speedster (I think or is it a Roadster) and I am going back for another fit with a different bike shop. I am lifting weights and doing ab exercises (I am a short fire hydrant shaped woman) and I think a large (or at least I hope) a large part of it is getting body used to new position.

I test rode a lot of bikes before I bought this one - A couple of shops in my area will let you try a bike out over a weekend before you buy it- that might help.