Well ...
First off, flexibility in forward bend is much more about hamstrings than low back. I speak from personal experience there - I can also bend my elbows with my palms on the floor, but my low back is EXTREMELY inflexible (even after doing my PT exercises for a year, it's way better than it was, but a lot of it is anatomical).
But, it's very common for a saddle to work for someone in a more upright riding posture but less so when they get more aero. (The saddle on my hybrid is one I took off my roadie, that was okay but not great on the not-even-super-aero road bike, but it's just dandy on the commuter. So much so that I can ride that bike in jeans with zero problems.)
I'm reading between the lines in your post that you've had fewer saddle issues when you set your bike up in a less aero position? It's certainly possible that a deep tuck just isn't going to work for you (was that your question?). But it's also possible that you just haven't found the right saddle.
Do you race, so that getting into a deep tuck is important to you (and so that you need a lighter saddle with a longer nose)? What issues have you had with the saddles you've tried? What size/shape/cutout do you need?



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