I'm a right-hander but I ended up buying a Timbuk2 bag that hangs from my right shoulder (technically the left-hander's bag). It's served me extremely well, and feels more natural than the right-handed configuration.
Also, hasn't anybody mentioned that Timbuk2 bags are waterproof? When I commuted with a backpack, I had to wrap it in a garbage bag to keep my clothes dry. No longer! It holds everything I need easily -- a medium bag can contain a full change of clothes, a jacket, and a good-sized lunch, plus three medium-sized books and quite a lot of miscellaneous stuff -- and I can access it quickly and easily.
In the interest of full disclosure: Clothes do tend to get crunched, and if you lean over real far on a road bike, it does tend to shift around some even cinched down real tight. Plus you can't carry tupperware in it very easily or you'll get bruises on your back.




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