I've had mixed sucess with tire liners. I had them in my old bike and I went about 15 years flat free - yes that's 15 years, with 700c tires. I put some in my winter bike this year and I got 3 flats in 2 days, 2 of them caused by the liner itself (one from the trainer rubbing over the overlap...). That was with 650's - I think that the liners just did not agree with those tires/wheels. I definitely like original Mr. Tuffys over slime liners - much easier to install properly.
I've never personally used tire sealants - though I bought a used disc wheel that already had it and it sure does work - but I don't know what brand - def. not slime since it was not green. That tire will leak slowly, but it will hold 150 psi for an hour or better, which is pretty good.
We also bought some slime for a friend of ours who uses a wheelchair and seemed to have perennial flats. He really loves it - he's not always pumping up his tires or listing to one side. Wheelchair tires generally are much lower pressure than bike tires though.



) When he flatted after me, I read the directions and shook the second can up and it worked just fine for him. He rides sew-ups. Does the fix-a-flat stuff work on regular tires if you actually follow the directions, or is it best for sew-ups? We were in a somewhat remote area and, if I were riding alone, I would prefer to use the fix-a-flat stuff because it was much faster than changing the tube.
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). But i insisted on changing it myself cos i know one day i'll have to do that on the road. Took me 45 minutes



