I will 2nd the notion to stick with the Synapse...although I'm partial to Shimano, so I would go for the Ultegra (which happens to be my current bike - Carbon Fem 3). I still need to dial in my fit a little better (I've had 3 professional fittings, with my most recent being a Retul fit) because I am still experiencing hand pain/numbness on every ride. Other than that issue, I really like the geometry of the Synapse because most of my riding is long distance (60-100 mile rides).
2012 Seven Axiom SL - Specialized Ruby SL 155