NSAIDS, renal problems and women

[WindingRoad]

I'm curious as to why women are more predisposed to experiencing renal complications due to prolonged NSAID use? I have been researching this topic and I find that in many cases is says women over 30 are much more at risk of developing this but no good and detailed description as to why??? I know several of you work in medicine so I thought I'd give it a shot on TE to see if anyone wants to share some info. I've determined a general cause that applies to men and women but I'm still not clear as to why women are MORE at risk. Basically it sounds that the NSAIDS impair the kidneys ability to concentrate urine properly. The only possible linking factor I ran across that makes sense is dehydration. Maybe due to monthly cycles women have more fluid loss? The typical patient that experiences analgesic nephropathy is considered to anemic, experience many headaches, female over 30 and had history of stomach ulcer. These are the signs the docs are supposed to look for. Any insight appreciated.

[Biciclista]

what is NSAID?

[indysteel]

what is NSAID?

Non-steroid anti-inflammatory drug. It refers, most commonly, to drugs like aspirin, ibuprofen, and naproxen.

[Biciclista]

thank you. I am more than normally freaked out about taking these medications, even under doctor's orders. My sister has had issues with her liver and never takes this stuff (nor does she take tylenol, i don't know how she survives!) I didn't know that there were more problems for women then men...

[zoom-zoom]

I know this much...a doctor buddy of mine makes a point of telling anyone who will listen to NEVER EVER take NSAIDS 6 hours before or after any endurance activity. Apparently the risk of renal failure is just too great under these circumstances. I have listened. A post-workout ice bath is safe and more effective, anyhow, IME. And pain is there for a reason. Sometimes masking it is courting worse pain in the end.

During a marathon I ran there were a couple of guys right behind me for the first 20+ miles who were popping Advil every hour. Made me cringe. Also made me wonder why they were running a marathon if they weren't ready or willing to endure some pain.

[OakLeaf]

Zoom-zoom, does that prohibition include a maintenance dose of baby aspirin?

[malkin]

I'm curious as to why women are more predisposed to experiencing renal complications due to prolonged NSAID use?

My guess:
Women are smaller than men and so the dose would be proportionally larger, causing more side effects.

I'm not looking for an argument, just making a guess.