Q-factor affects foot, ankle, knee and hip alignment, in other words: the joints. It seems that women are more prone to noticing it than others. I can feel it on our tandem since I've got both the triple crank and the timing chain crank to deal with. Q-factor has nothing to do with calf size (though some people may be jealous of nice calves
).
The crank and the pedal can affect the q-factor. Not all cranks have the same width whether they are double, triple or whatever. Each crank must be measured individually and the same for pedals.
One idea is to look for pedals with a narrow q-factor or a replaceable spindle upgrade like a Crank Bros. They have a shorter spindle available, but I also know some of their pedals have a narrower q-factor to begin with than others.
Frends know gud humors when dey is hear it. ~ Da Crockydiles of ZZE.