There's such a knowledgeable community of folks with thyroid issues here that I bet someone else has thought about this: does anyone modify their thyroid-medication schedule when planning things that go late into the night, especially athletic-y ones? I feel like I can feel the levothyroxine wearing off at about 11pm (I take it at about 7am normally), and I can definitely feel it kick in in the morning. So I'm wondering about what people do when doing brevets/other long rides that run late (or start in the middle of the night). Take the dose earlier/later? Take it on time and just deal with the exhaustion? Take smaller doses and spread throughout the day? (It looks like it's a safe pill to cut -- no fancy extended-release, though I'd obviously check with my doc about that.)