Do you have to point your toes to reach the pedal at the bottom of the pedal stroke? Are you having calf or ankle trouble because of that? Are you having knee trouble because your knees are flexing too much at the top of your pedal stroke? Do you prefer pedaling at higher RPMs?
ETA ... your actual question was whether I noticed a difference. I'm usually better about reading posts before responding to them. 
Yes. Enormous difference. Unbelievably enormous. Besides solving my knee and Achilles tendon injuries, 165s are just plain more comfortable for me.
Last edited by OakLeaf; 08-01-2011 at 07:00 PM.
Speed comes from what you put behind you. - Judi Ketteler