I've done Mt. Elbert, right next door!
I used to only hike, and never had any real soreness issues. What I've noticed is that since I started biking, my calf muscles are really tight, and VERY sore after I hike. Seems like biking shortens the muscle, while it needs to over-extend for hiking uphill. Whenever someone who bikes starts talking about a hiking trip, I advise them to start stretching those calves immediately.