Just to let you know, bikers of all sizes have saddle problems. So, don't think that just because you are 6'2 and 320 pounds that you are having pain issues when you bike. As an encouragement, besides enjoying biking, we have had a lot of TE members lose a TON of weight because of their love for biking.
There have been multiple threads on saddles as this is a common problem. In fact, see if you can find a store that has demo saddles for you to try. Maybe you should look at the SMP PLUS saddle first. I personally like saddles with huge cut-outs. In addition, some women like chamois in their bike shorts while others prefer bike shorts without padding.
Same with the gloves, some think the padding on gloves helps while other disagree. Unfortunately, the aching of the palms could also be a fit issue. If you are too far backward or the handlebars are not high enough for you, you might be having palm pain. How do you know the problem? Get a bike fit.
My recommendation is to work on the saddle issue first and try different types of gloves. If these basic recommendations don't help, you might want to consider a bike fit, which is expensive but well worth the money, especially if you think that you could really enjoy biking once the pain issues are resolved.