I don't use the big ring much on my bike due to knee issues, but I have similar experience when in the small ring and smallest cog. It's that way regardless of any adjustments that are done on my derailleurs.
So I only ride in that combination for short stretches, otherwise I shift up to the big ring.
- Gray 2010 carbon WSD road bike, Rivet Independence saddle
- Red hardtail 26" aluminum mountain bike, Bontrager Evoke WSD saddle
- Royal blue 2018 aluminum gravel bike, Rivet Pearl saddle
Gone but not forgotten:
- Silver 2003 aluminum road bike
- Two awesome worn out Juliana saddles