For a front wheel, I might put the bike on its side, but for a rear wheel change I find it easier to get the wheel on and off with the bike upside-down. But then I generally don't have trouble turning the bike upside-down -- that's also how I clean and lube the chain.
If you do have it upside-down, make sure you get anything you need out of the bike bag(s) while it's still upright.
- Gray 2010 carbon WSD road bike, Rivet Independence saddle
- Red hardtail 26" aluminum mountain bike, Bontrager Evoke WSD saddle
- Royal blue 2018 aluminum gravel bike, Rivet Pearl saddle
Gone but not forgotten:
- Silver 2003 aluminum road bike
- Two awesome worn out Juliana saddles