Oh, man, I'm wondering the same thing. The saddle sore was a good hint (and they got a black mark on their label), but putting more chamois butter helped that. Now, I'm just finding that I'm choosing other shorts first, and saving the questionable ones for short rides. I'll do that for a while. Eventually, I suspect they will find a rest spot in the bottom of a drawer, to be discovered while looking for a missing glove someday. Then I'll toss them.
'02 Eddy Merckx Fuga, Selle An Atomica
'85 Eddy Merckx Professional, Selle An Atomica
'10 Soma Double Cross DC, Selle An Atomica
Slacker on wheels.