I definitely need some kind of chamois lube. Makes a huge difference. I've found I'm not uber-picky about brand -- I have some slight preference for some over others, but most of what I've tried does the job (Assos, Chamois Buttr, Bodyglide, Nu Butte).

I will say that somebody on here recommended Astroglide as a chamois lube and that didn't work for me at all. It seemed to sweat right off.