It's normal to be a little sore between the shoulders or on your butt or other areas after a long ride or a hard ride, but it's really not good for the bike to feel uncomfortable during the entire ride or on shorter, less strenuous rides. Saddles are a crazy thing.. what works for one person might not for someone else and we each need to find what works for our anatomy. So listen to your body and if something hurts from the git-go, it probably needs some sort of adjustment.
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"I never made "Who's Who"- but sure as hell I made "What's That??..."