My girlfriend had 650 c wheels on her Trek 2300 but we found she was always the one to get TWO flats on group rides, and the rest of us have 700c so couldn't help out. She loves the road sparkles!
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I have a Trek Madone SSL 6.9. I have an aluminum LeMond Tourmalet that I love and I originally ordered a carbon Zurich, but there were really lengthy delays in production and my bike shop guy talked me into the Trek.
I have a beef with most of the bike companies not making a women's specific version of their best bikes. My bike is a men's 50 cm. I am 5'5", with kind of longish legs.