I did, but not on the road. I tried two different versions at my fitter (but I don't recall which ones, exactly) but the noses were too wide for me so I didn't ride them but for a few minutes.
My issue was multi-faceted, but I needed a wide channel for the girly bits/soft tissue, but a narrow nose because my hips are narrow while my legs are large. The wider noses of most cut-out saddles rubbed my leg crease or inner thighs raw. The narrow noses either didn't have a cut out (pure, instant pain in aero) or they did, but with use, actually pinched my soft tissue!
At the time, I was much heavier than I am now though, so my legs were significantly larger. I might be able to stand a wider nose now that I'm smaller (too bad I no longer have a tri bike!).

