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I have a compact double with a 46 - 33 in the front, 11 - 34 in the rear. I spent most of the ride in the 34. :D There were a couple of sections where it did flatten out a bit and I shifted up a few gears. I only stood once and not for very long. That would be where my heart rate went up to 191, I think.
V.
I am late reading this but wow! After driving north of the bay when we visited I don't know how you gals do it. We drove out to Muir Woods (and I think Mount Tamalpais), I almost vomitted coming down the hills. I RARELY get car sick but some of those roads had me a little woozy. And I saw plenty of cyclists just plugging along.