Riding around with mixed wheel set-up?

I have a question and I know it's probably nuts, but my husband is an avid mountain biker and we know quite a few people who ride around on 69'ers, 26" wheels in the back and 29" (it rolls over stuff better and local racers praise 'em) in the front and they love the combination. I was wondering if that could translate to a road bike, 650 in the back and 700 in the front. My husband just suggested the idea because he thinks it could help a little with my comfort on a rode bike.

My husband mentioned that 1998 Tour De France, Marco Pantani did the opposite rode with a 650c front and 700c rear for his time trials to make him more aerodynamic.

What do you all think?

Terry Cycles did 700c in back and 650 or smaller in front for a long time. Don't know of any examples the other way around.

P2

I can't see how a 650c rear would do anything to help your comfort :confused: but it will probably kill your geometry = handling. The brakes might not reach either, but you can retrofit long reach brakes. But if you want to try, gently shove in a 26in mtb wheel (only 12mm circumference difference to a 650)and see if you like it as a chopper. What is the problem with your roadie set up?

I second the question about fit on your roadie. The thing about the 29" wheel on a mnt bike is the ease of rolling over obaticals, like roots and rocks, so I'm not all that sure two different sized wheels on a road bike would get you where you want to be... IMHO.

Shannon