Quads, hamstrings and clipless

Can moving from platforms to clipless (dual sided - platform/spd) pedals cause quad or hamstring soreness. I've only ridden 60 miles this week on clipless (not counting any riding with non-cleated shoes) and not all at once. However I do have some soreness about mid-thigh on the back.

Of course my trainer also put me on a new leg-press machine this week that has me in a different position. I do a fair amount of weight on leg-presses but to my understanding this does not target my hammies. I could be wrong though... just trying to decide my riding/work schedule for the weekend and how much attention to pay the soreness. Knowing where it is likely from would be helpful.

Added: A little more research has shown that it is possible the new leg-press machine may well be the root of this. He moved me from the main leg-press machine to where the position is close to a normal seated position to a machine with a far more reclined position that has to work different muscle groups - or at least in a different way. This seems to be more likely the issue rather than moving to clipless. I would assume that might impact the calves and quads more?

You may have found your answer, but I wanted to add my two cents:

My first clipless ride, I did about 24 miles (a distance I'd done before), but without having ridden for a few months.
My quads were happy...at least, less sore than they had been for that distance with that long a break. My hamstrings were screaming at me when I got off the bike. I certainly utilized that ability to pull up that does tax your hamstrings, so my quads got a break while my hamstrings had to do more work than they were used to.

I do wonder if this is part of my quad soreness. The hip flexor soreness is from the MT I allowed to stretch my Sunday before my ride - and it is feeling better today. I suspect the quad soreness is a combination of moving to clipless, use of a reclined leg-press machine by my trainer last week, and pushing things a little too hard/far on Sunday on the bike. Things seem to be starting to feel better though, and am off the bike until spinning class Thursday (will take that very lightly).

Hoping to make a charity ride Saturday :)

Thanks for your experience with this, it is helpful!