Tried a new solution today (a bit graphic)
I'm an OB nurse so I'm not embarrassed to be graphic about the nether regions (but feel free to skip if you are!)
Been struggling a lot with this especially when we ride on "chip and seal" (rough surface) roads. The irritated tissue has been in many different places (inner labia, outer labia, etc, depending on how I was sitting I suppose.) I tried antibiotic ointment the first time it happened (didn't seem to help), and I've iced my perineum after my rides to diminish swelling and numb the pain (provides temporary relief but little else). Today I tried a different approach based on something DH told me: He said, "Deb, when I ride I have to 'rearrange things' down there every now and then to stay comfortable." Now, we know men 'rearrange things' down there as a way of life, but for women, it's rarely necessary. But on the bike, we have all those delicate folds of tissue and that's where some of my probem was coming from.
When DH went through radiation treatment at MD Anderson, they gave us a huge jar of Aquaphor ointment to use on his burned skin. Before my ride today, I coated my perineum with it (very greasy stuff, admittedly) but I found that the ointment lubed things up a lot down there so all I had to do was "ooch and scootch" a bit on my saddle, and it rearranged my parts whenever I felt a bit of pressure. Voila - I got off the bike, took a shower and NOTHING hurts!
Now, one time is not "proof" - it might've just been a lucky day. But I'm going to keep trying it. It can't hurt. It contains petrolatum and lanolin alcohol (and I had to look up what lanolin alcohol is: Lanolin Alcohol = Highly-refined fatty alcohol emollient, derived from lanolin, rich in skin-softening cholesterol.)
Thought I'd share...
Deb